Rebel-held areas of Aleppo in Syria have suffered their most intense airstrikes in months, according to reports.
The development comes ahead of a meeting at the UN of the International Syria Support Group, made up of about 20 countries with interests in the conflict, including the US and Russia.
All the key players in the civil war will resume diplomatic efforts in New York to save the troubled ceasefire deal.
On Wednesday, US Secretary of State John Kerry and Russian foreign minister Sergey Lavrov blamed each other for violating the agreement.
Mr Kerry called for Russian and Syrian government aircraft to be grounded in parts of the country so the deal can be extended.
He wants all warplanes to halt flights over aid routes, while Mr Lavrov suggested a possible three-day pause in fighting to get the truce back on track.
Speaking at the UN, Mr Kerry said it was the last chance to salvage the collapsing deal and find a way "out of the carnage" but the future of the country was "hanging by a thread".
He also said an airstrike on a Red Cross convoy in Aleppo on Monday raised "profound doubt" as to whether Russia and the Syrian government were committed to upholding the cessation of hostilities.
The US has said based on timing and location it was Russian jets which hit the convoy that killed 20 aid workers delivering humanitarian supplies.
Moscow has denied responsibility for the attack.
The Syrian military has not yet commented on the claims about the latest intense airstrikes which were made by rebel officials and a monitoring group.
After halting aid operations in the wake of the attack on the convoy, the UN has said it is ready to resume humanitarian deliveries.
Sounding a cautious note, Mr Kerry told reporters late on Wednesday that "it's going to be difficult. We'll see what people are willing to do."
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