Angelina Jolie has filed for dissolution of her marriage to husband Brad Pitt, according to a lawyer for the actress.
Robert Offer said in a statement that Jolie's decision had been made "for the health of the family".
He added: "She will not be commenting and asks that the family be given privacy at this time."
Jolie, 41, cited irreconcilable differences with Pitt, listing their date of separation as 15 September.
The nature of the differences have not been revealed but TMZ reports that there was conflict over Pitt's parenting, with a source saying Jolie was "extremely upset with his methods".
The couple have six children - Maddox, 15, Pax, 12, Zahara, 11, Shiloh, 10, and twins Knox and Vivienne, 8 - and Jolie is believed to be seeking custody of them.
She and Pitt married in a private ceremony in France in 2014 but they had been together since 2004.
They first met on the set of the film Mr And Mrs Smith, while Pitt was still married to Friends star Jennifer Aniston.
Jolie had been married twice before - to actors Jonny Lee Miller and Billy Bob Thornton.
Jolie is being represented in these proceedings by divorce lawyer Laura Wasser, who helped her in her divorce from Thornton and is also representing Johnny Depp in his divorce from Amber Heard.
As well as their film careers, Pitt and Jolie are both known for charitable work: they set up the Maddox Jolie-Pitt Foundation 10 years ago to assist in humanitarian crises around the world, launching it with a $1m donation to Doctors Without Borders.
Jolie represented the UN High Commission for Refugees as a Goodwill Ambassador between 2001 and 2012, becoming a Special Envoy in April 2012.
She has also been a well-known symbol in the battle against cancer, having undergone a double mastectomy and removal of her ovaries and fallopian tubes to prevent an aggressive form of the disease that killed her mother, aunt and grandmother.
Pitt started the Make It Right Foundation after Hurricane Katrina in 2005, donating $5m to help rebuild New Orleans after the disaster.
The 52-year-old is currently focusing on opening a luxury resort in Croatia.
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