The US President said he would be "delighted" to "help" the boy after doctors won a definitive court case to end his life-support treatment.
Charlie suffers from a rare genetic condition and has brain damage.
Mr Trump waded into the debate by referencing Pope Francis' plea for the toddler's parents to be allowed to "accompany and treat their child until the end".
The US President wrote on Twitter: "If we can help little #CharlieGard, as per our friends in the U.K. and the Pope, we would be delighted to do so."
Image:Donald Trump at a meeting with South Korea's Moon Jae-in on 30 June, 2017.After, Charlie's parents Connie Yates and Chris Gard posted a link to the tweet on their campaign Facebook page with heart emojis and the message: "If he's still fighting, we're still fighting!!! Xxx."
The pair had raised £1.3m in donations to fly Charlie to the US for treatment known as nucleoside bypass therapy.
But medics at Great Ormond Street Hospital fought the bid, saying the operation was experimental and would not help him.
Judges in the High Court, Court of Appeal and the Supreme Court ruled against the parents and in favour of the doctors.
On Tuesday, the European Court of Human Rights refused to intervene.
Image:Connie Yates and Chris Gard with their son Charlie GardMr Gard and Ms Yates said afterwards that they were told Charlie would have his life support switched off on Friday.
The pair claimed they were denied their final wish to take him home to die.
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