President Barack Obama has said the "special relationship" between the UK and US will endure following the Brexit referendum result.
Mr Obama, who had warned against Britain quitting the European Union, said on Friday that Washington would respect the British voters' decision to do just that.
Mr Obama used a high-profile visit to London in April to warn that Britain would be at the "back of the queue" for a trade deal in the event of Brexit.
But in a statement issued by the White House following the historic referendum result, Mr Obama said both the UK and European Union would remain "indispensable partners".
"The special relationship between the United States and the United Kingdom is enduring, and the United Kingdom’s membership in NATO remains a vital cornerstone of US foreign, security, and economic policy," he said.
"The United Kingdom and the European Union will remain indispensable partners of the United States," he added.
Wall Street opened sharply lower on Friday after Britain's vote to quit the European Union delivered the biggest blow to the global financial system since the 2008 financial crisis.
US Treasury Secretary Jack Lew said: "We will work closely with both London and Brussels and our international partners to ensure continued economic stability, security, and prosperity in Europe and beyond."
But Republican White House candidate Donald Trump said the UK voting to leave the European Union is a "great thing".
Speaking at his Trump Turnberry golf resort in Scotland, the tycoon said: "It's an amazing vote, very historic."
Prime Minister David Cameron announced his resignation after the result became clear, claiming the UK needed "fresh leadership" as it leaves the EU.
He had campaigned to remain, but the public rejected his arguments and chose to leave by 51.9% to 48.1%.
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