The Met Office said "in excess of 150 to 200mm" of rain could fall on Cumbria as Storm Desmond swept in.
"In view of flooding and further disruption to transport being expected take action to remain safe and protect property," it said in its red warning.
Sixty-one flood warnings for elsewhere in the north of England have also been issued by the Environment Agency.
In Scotland, Desmond has already caused flooding and a landslides, closing roads some roads. Flood warning have been issued for the majority of its rivers.
A 15-mile stretch of the A82 was shut after at least 200 tonnes of debris slipped from a hillside above Altura in the Highlands. Several areas of the road were also flooded.
Sky's weather presenter Nazaneen Ghaffar said Scotland, northern England, Ireland and northwest Wales would "remain wet all day".
"The winds will be disruptive and damaging today as well, with gusts up to 60mph for inland areas, and maybe in excess of that around exposed coasts and across hills."
Among the other Scottish roads affected by the weather are:
:: The A924 slip road into Pitlochry from the A9 was closed after the River Tunnel burst its banks.
:: The M8 at Bathgate, West Lothian, was closed after a jack-knifed FedEx truck hit the central reservation.
:: There has been flooding on the A85 at Loch Lubhair. The road is passable with care but the water level of the loch continues to rise.
::The M90 was closed between junctions 8 and 9 due to flooding near Glenfarg in Perthshire. Traffic was diverted via the A91 and A912.
:: The M9 was closed eastbound from junction 11 at the Keir Roundabout to junction 9 due to flooding.
:: There is heavy surface water and flooding on the A977 on the approach to the Clackmannanshire Bridge at the Gartarry Roundabout.
Bear Scotland, which operates trunk roads in the region, said staff were out overnight dealing with numerous reports of flooding, debris on the road and fallen trees.
RAC spokesman Simon Williams saying that anyone driving in Scotland on Sunday may continue to be faced with "extremely challenging conditions" - possible flooding, wind damage debris and more high winds.
"Motorists encountering floodwater on the road should think twice before trying to drive through. Water getting sucked into engines can cause catastrophic damage which could lead to a frightening repair bill at the most expensive time of year or even an insurance write-off.
"If you are at all unsure how deep a flood is, the best advice is to err on the side of caution and take another route."
Highways England issued a severe weather alert for high-sided vehicles, caravans and motorcycles in the north.
The A66 was closed to high-sided and vulnerable vehicles between junction with the A67 near Bowes in County Durham and the A685 at Brough in Cumbria.
The A19 Tees Viaduct in Middlesbrough was closed to high-sided traffic in both directions between the A66 and A1046 after reports of strong winds. There are local diversions.
In Dublin, some UK and international flights were cancelled and customers were advised to visit airline or Dublin Airport websites for further flight information.
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