Two hundred firefighters and 40 fire engines are battling a large fire on a west London estate.
At least two people have been injured and flats at the 27-storey Grenfell Tower are being evacuated.
Footage on social media showed the building engulfed in fire, with flames stretching over a number of floors.
The fire brigade said the fire had spread throughout the entire building.
London Fire Brigade assistant commissioner Dan Daly said: "Firefighters wearing breathing apparatus are working extremely hard in very difficult conditions to tackle this fire.
"This is a large and very serious incident and we have deployed numerous resources and specialist appliances."
One witness, Reo, told Sky News: "I was in my kitchen and heard smoke alarms.
"I could see the whole right side of the building was on fire."
Image:The fire at Grenfell Tower is in Latimer Road in west London
Celeste Thomas lives across the road from the tower and said residents and families were "trying to find each other" following the evacuation.
She said: "Police have moved everyone back out of direct sight but I can hear cracking and debris falling."
The tower block is on the Lancaster West Estate, between Latimer Road Underground station and Westfield's White City shopping centre.
Police said: "At this stage we are aware of two people being treated at the scene for smoke inhalation."
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